Effect of panax notoginseng saponins on atherosclerosis with type 2 diabetes mellitus in goto-kakizaki rats by nuclear factor-kappa b signaling pathway
By: Jiang, L. Y
.
Contributor(s): Cai, C.
Publisher: Mumbai Indian Journal of Pharmaceutical Science 2022Edition: Vol.84(5), Sep-Oct.Description: 1248-1256p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Indian journal of pharmaceutical sciencesSummary: To explore the effect of Panax notoginseng saponins on atherosclerosis with type 2 diabetes mellitus in
Goto-Kakizaki rats by nuclear factor-kappa B signaling pathway. Goto-Kakizaki rats fed with high fat
diet and injected with N-nitro-L-arginine methyl ester for 8 w, were randomized into model group and
Panax notoginseng saponins group (400 mg/kg/d). Another Goto-Kakizaki rats and Wistar rats were
selected as Goto-Kakizaki group and control group which fed with normal diet and injected with saline.
Serum lipid and inflammatory factors were measured. There were no statistical differences of lipid profiles
between model group and Panax notoginseng saponins group (p>0.05). In Panax notoginseng saponins
group, serum tumor necrosis factor-alpha, interleukin-6, intercellular adhesion molecule-1, vascular cell
adhesion molecule-1 and monocyte chemotactic protein-1 were significantly decreased (p<0.01), messenger
RNA expression and protein levels of interleukin-6, tumor necrosis factor-alpha, intercellular adhesion
molecule-1, vascular cell adhesion molecule-1, monocyte chemotactic protein-1 and nuclear factor-kappa
B in the Panax notoginseng saponins group were significantly lower, compared with those in model group
(p<0.05, p<0.01). Some inflammatory factors in model group were higher than those in Goto-Kakizaki
group which were higher than those in control group. The inflammatory reaction with nuclear factor-
kappa B signaling pathway as core, occurs throughout type 2 diabetes mellitus and its atherogenesis and
Panax notoginseng saponins improves nuclear factor-kappa B signaling pathway, decreasing its related
inflammatory factors to achieve an improvement in the diabetic atherosclerotic process.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|
Articles Abstract Database
|
School of Pharmacy Archieval Section | Not for loan | 2023-1137 |
To explore the effect of Panax notoginseng saponins on atherosclerosis with type 2 diabetes mellitus in
Goto-Kakizaki rats by nuclear factor-kappa B signaling pathway. Goto-Kakizaki rats fed with high fat
diet and injected with N-nitro-L-arginine methyl ester for 8 w, were randomized into model group and
Panax notoginseng saponins group (400 mg/kg/d). Another Goto-Kakizaki rats and Wistar rats were
selected as Goto-Kakizaki group and control group which fed with normal diet and injected with saline.
Serum lipid and inflammatory factors were measured. There were no statistical differences of lipid profiles
between model group and Panax notoginseng saponins group (p>0.05). In Panax notoginseng saponins
group, serum tumor necrosis factor-alpha, interleukin-6, intercellular adhesion molecule-1, vascular cell
adhesion molecule-1 and monocyte chemotactic protein-1 were significantly decreased (p<0.01), messenger
RNA expression and protein levels of interleukin-6, tumor necrosis factor-alpha, intercellular adhesion
molecule-1, vascular cell adhesion molecule-1, monocyte chemotactic protein-1 and nuclear factor-kappa
B in the Panax notoginseng saponins group were significantly lower, compared with those in model group
(p<0.05, p<0.01). Some inflammatory factors in model group were higher than those in Goto-Kakizaki
group which were higher than those in control group. The inflammatory reaction with nuclear factor-
kappa B signaling pathway as core, occurs throughout type 2 diabetes mellitus and its atherogenesis and
Panax notoginseng saponins improves nuclear factor-kappa B signaling pathway, decreasing its related
inflammatory factors to achieve an improvement in the diabetic atherosclerotic process.
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